UVB represses melanocyte cell migration and acts through β-catenin.
Identifieur interne : 000114 ( Main/Exploration ); précédent : 000113; suivant : 000115UVB represses melanocyte cell migration and acts through β-catenin.
Auteurs : Juliette U. Bertrand [France] ; Valérie Petit [France] ; Elke Hacker [Australie] ; Irina Berlin [France] ; Nicholas K. Hayward [Australie] ; Marie Pouteaux [France] ; Evelyne Sage [France] ; David C. Whiteman [Australie] ; Lionel Larue [France]Source :
- Experimental dermatology [ 1600-0625 ] ; 2017.
Abstract
The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. β-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on β-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of β-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases β-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the β-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3β, and decreased by an inhibitor of β-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-β-catenin axis.
DOI: 10.1111/exd.13318
PubMed: 28191677
Affiliations:
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Bertrand</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Petit, Valerie" sort="Petit, Valerie" uniqKey="Petit V" first="Valérie" last="Petit">Valérie Petit</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Hacker, Elke" sort="Hacker, Elke" uniqKey="Hacker E" first="Elke" last="Hacker">Elke Hacker</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Berlin, Irina" sort="Berlin, Irina" uniqKey="Berlin I" first="Irina" last="Berlin">Irina Berlin</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K" last="Hayward">Nicholas K. 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Whiteman</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Larue, Lionel" sort="Larue, Lionel" uniqKey="Larue L" first="Lionel" last="Larue">Lionel Larue</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author></analytic><series><title level="j">Experimental dermatology</title><idno type="eISSN">1600-0625</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. β-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on β-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of β-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases β-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the β-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3β, and decreased by an inhibitor of β-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-β-catenin axis.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><settlement><li>Orsay</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Bertrand, Juliette U" sort="Bertrand, Juliette U" uniqKey="Bertrand J" first="Juliette U" last="Bertrand">Juliette U. Bertrand</name></noRegion><name sortKey="Berlin, Irina" sort="Berlin, Irina" uniqKey="Berlin I" first="Irina" last="Berlin">Irina Berlin</name><name sortKey="Larue, Lionel" sort="Larue, Lionel" uniqKey="Larue L" first="Lionel" last="Larue">Lionel Larue</name><name sortKey="Petit, Valerie" sort="Petit, Valerie" uniqKey="Petit V" first="Valérie" last="Petit">Valérie Petit</name><name sortKey="Pouteaux, Marie" sort="Pouteaux, Marie" uniqKey="Pouteaux M" first="Marie" last="Pouteaux">Marie Pouteaux</name><name sortKey="Sage, Evelyne" sort="Sage, Evelyne" uniqKey="Sage E" first="Evelyne" last="Sage">Evelyne Sage</name></country><country name="Australie"><noRegion><name sortKey="Hacker, Elke" sort="Hacker, Elke" uniqKey="Hacker E" first="Elke" last="Hacker">Elke Hacker</name></noRegion><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K" last="Hayward">Nicholas K. Hayward</name><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C" last="Whiteman">David C. Whiteman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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